Drug interactions, such as a heightened incidence of extrapyramidal results, are actually documented when some MAOI and phenothiazines are utilized concomitantly.
Codeine has superior antitussive action, Despite the fact that lower than that of morphine at equivalent doses. It's Employed in desire to morphine, since Unwanted side effects are infrequent at the standard antitussive dose of codeine.
Sedating medicine may perhaps cause confusion and around-sedation during the elderly; elderly people generally ought to be begun on small doses of Promethazine HCl Oral Alternative and noticed carefully.
Caution must be exercised when promethazine hydrochloride and codeine phosphate syrup is administered to your nursing woman.
Existence-threatening respiratory despair and Loss of life have transpired in little ones who gained codeine; most situations adopted tonsillectomy and/or adenoidectomy, and lots of of the children had proof of currently being an ultra-immediate metabolizer of codeine as a consequence of a CYP2D6 polymorphism. (5.three) Promethazine HCl and Codeine Phosphate Oral Answer is contraindicated in small children youthful than twelve a long time of age As well as in kids youthful than eighteen a long time of age next tonsillectomy and/or adenoidectomy.
Lengthy-term animal experiments haven't been carried out to evaluate the carcinogenic likely of promethazine, nor are there other animal or human info concerning carginogenicity, mutagenicity, or impairment of fertility with this drug. Promethazine was nonmutagenic while in the Salmonella examination program of Ames.
If the patient develops these signs or signs, elevate the dose to your past stage and taper far more slowly and gradually, both by escalating the interval in between decreases, decreasing the level of adjust in dose, or equally.
The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complex, requiring careful consideration of the consequences about the parent drug, codeine, and the Lively metabolite, morphine.
Promethazine HCl Oral Resolution may perhaps lower seizure threshold. It ought to be employed with warning in folks with seizure Ailments or in persons who're making use of concomitant remedies, such as narcotics or local anesthetics, which can also impact seizure threshold.
The respiratory melancholy will involve a discount during the responsiveness of the brain stem respiratory centers to both improves in carbon dioxide stress and to electrical stimulation.
Will not utilize a family teaspoon to measure your medicine. It's possible you'll accidentally take a lot of. You may inquire your pharmacist with the measuring device it is best to use and how to measure here the proper dose.
Pediatric people ought to be supervised to prevent likely damage in bicycle Using or in other dangerous pursuits.
The causal purpose of opioids while in the clinical syndrome of hypogonadism is unfamiliar because the several health care, Actual physical, Way of living, and psychological stressors that will influence gonadal hormone amounts haven't been adequately controlled for in scientific tests executed up to now [see Adverse Reactions (six)].
Sedating medicines may perhaps trigger confusion and about-sedation in the elderly; elderly sufferers frequently ought to be commenced on small doses of Promethazine HCl Oral Answer and observed closely.